Chondrocyte ultrastructure in adult human articular cartilage.

Chondrocyte ultrastructure in adult human articular cartilage.

Age changes in the ultrastructure of articular chondrocytes have been studied in detail in mice (Silberberg, Silberberg, and Feir, 1964) and in rabbits (Davies, Barnett, Cochrane, and Palfrey, 1962; Barnett, Cochrane, and Palfrey, 1963). Less has been published concerning the influence of age on cellular ultrastructure in human articular cartilage. This is due partly to the scarcity of suitable...

Osmolarity influences chondrocyte repair after injury in human articular cartilage

BACKGROUND The purpose was to determine the influence of irrigation solution osmolarity on articular chondrocytes survival and metabolic state following mechanical injury. METHODS Osteochondral explants were harvested from patients undergoing total knee arthroplasty for osteoarthritis and then cut through their full thickness to establish mechanical injury models. Cartilage explants were incu...

Chondrocyte multiplication in osteoarthritic articular cartilage.

Characterization of polydactyly-derived chondrocyte sheets versus adult chondrocyte sheets for articular cartilage repair

Background We previously conducted a first-in-human clinical study of articular cartilage repair using autologous chondrocyte sheets and confirmed the regeneration of hyaline-like cartilage in all eight patients. However, regenerative medicine with autologous chondrocyte sheets requires the harvesting of tissue from healthy regions, and the quality of this tissue varies between individuals. To ...

Chondrocyte biosynthesis correlates with local tissue strain in statically compressed adult articular cartilage.

In this study, we investigated the depth-dependent metabolic and structural responses of adult articular cartilage to large-strain, static, unconfined compression. Changes in cell biosynthetic activity and several morphometry-based structural parameters (cell density, cell volume fraction, cell surface-area density, mean cell surface area, and mean cell volume) were measured at eight sites repr...